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KMID : 1161420180210020199
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Journal of Medicinal Food
2018 Volume.21 No. 2 p.199 ~ p.202
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Apiaceous Vegetables and Cruciferous Phytochemicals Reduced PhIP-DNA Adducts in Prostate but Not in Pancreas of Wistar Rats
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Kim Jae-Kyeom
McCormick Marissa A.
Gallaher Cynthia M.
Gallaher Daniel D.
Trudo Sabrina P.
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Abstract
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We previously showed rats fed with apiaceous vegetables, but not with their putative chemopreventive phytochemicals, reduced colonic DNA adducts formed by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a dietary procarcinogen. We report here the effects of feeding apiaceous and cruciferous vegetables versus their purified predominant phytochemicals, either alone or combined, on prostate and pancreatic PhIP-DNA adduct formation. In experiment I, male Wistar rats received three supplemented diets: CRU (cruciferous vegetables), API (apiaceous vegetables), and CRU+API (both types of vegetables). In experiment II, rats received three diets supplemented with phytochemicals matched to their levels in the vegetables from experiment I: P?+?I (phenethyl isothiocyanate and indole-3-carbinol), FC (furanocoumarins; 5-methoxypsoralen, 8-methoxypsoralen, and isopimpinellin), and COMBO (P?+?I and FC combined). After 6 days of feeding, PhIP was injected (10?mg/kg body weight) and animals were killed on day 7. PhIP-DNA adducts were analyzed by LC-MS/MS. In prostate, PhIP-DNA adducts were reduced by API (33%, P?
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KEYWORD
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2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, apiaceous vegetables, cruciferous vegetables, DNA adducts, heterocyclic aromatic amines
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